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Melanotan II TOP

Melanotan and melanotan II are both analogs of the peptide hormone alpha-melanocyte stimulating hormone (a-MSH) that tend to induce skin tanning. Unlike melanotan though, melanotan II has the additional effect of increasing libido.   Both drugs were developed at the University of Arizona . Researchers there knew that one of the best defenses against skin cancer was a natural tan which has been slowly developed over weeks.

MPT141 TOP

If PT141 is approved by the FDA in 2007 it will have the most revolutionary effect on women’s sex lives since the availability of the birth control pill in the early 1960’ s. Unlike sexual enhancement drugs for men such as Viagra, Levitra, and Cialis, there are no drugs currently available for women with sexual dysfunction problems.  If current studies being conducted by Palatin Technologies on the treatment of female sexual dysfunction problems are any indication, PT141 could be the first drug available to boost female sexual desire. Tests conducted on rats have shown “significantly enhanced” sexual behavior.  What scientists have observed is that when given PT141, female rats actually sought male rats for sex. Jim Pfaus, a professor of psychology at Concordia University in Montreal , who along with Palatin Technologies has been researching PT141, believes it “could be bigger than Viagra.” Palatin has conducted a two phase study with 50 pre-menopausal without sexual dysfunction and found that women taking PT141 reported an increase in their level of sexual desire and genital arousal compared to a placebo. Because female sexual dysfunction involves problems with desire, arousal, orgasm and pain, PT141 could be beneficial for both women with female sexual dysfunction (women who are interested in sex, but cannot reach a climax) as well as women who have a lack of desire for sex and not physiological problems. This is because PT141 works to activate receptors in the central nervous system to increase desire for sex while also increasing blood flow to the genital area thus improving both sexual desire and sexual function With the aging “baby boom” generation, both men and women who suffer from sexual dysfunction are a growing market and PT141 shows potential to be more effective than Viagra in treating sexual dysfunction with minimal side effects. Based on studies thus far, PT141 shows promise to bring new found sexual enjoyment for women who have suffered from decreased sexual function and have not had the benefit of sexual enhancement drugs on the market. How PT141 works Because PT141 directly targets the brain’s arousal center and doesn’t just work with the vascular system to increase blood flow to the genital area, it has the potential to treat women with sexual dysfunction problems, especially those with lack of sexual desire. For women, PT141 works twofold in that it increases sexual desire and function. For men it is primarily is used for erectile dysfunction (ED), but for women it has been shown to increase the desire for sex and well as the enjoyment of sex. PT141 is taken approximately 30 minutes before sexual activity and is nasally administered. It is non-invasive and fast acting. PT141 does not interact with other drugs, food or alcohol and has minimal side effects.

MGF TOP

MGF is a prime candidate for gene doping for enhancement of athletic performance. MGF can produce rapid increases in muscle and strength, giving it considerable therapeutic and doping potential. Its potential for optimising physical training. This is better way of life! We can provide high quality MGF as very comparative price. 1mg/vial or 2mg/vial Worldwide shipment Let’s start with an explanation of Mechano Growth Factor (MGF) and what it does. The muscle insulin-like growth factor-I (IGF-I) mRNA splice variant (IGF-IEc) has been identified in rodents. IGF-IEc, also called mechano growth factor (MGF) has been found to be up-regulated by exercise or muscle damage. Growth hormone (GH) is the principal regulator of IGF-I expression in several tissues including the skeletal muscle. MGF is derived from IGF-I but its sequence differs from the systemic IGF-I produced by the liver. MGF is expressed by mechanically overloaded muscle and is involved in tissue repair and adaptation. It is expressed as a pulse following muscle damage and is apparently involved in the activation of muscle satellite (stem) cells. These donate nuclei to the muscle fibres that are required for repair and for the hypertrophy processes which may have similar regulatory mechanisms (Goldspink, G., 2005, p. 22). The C-terminal peptide MGF, an alternatively spliced variant IGF-1, was found to function independently from the rest of the molecule. At any rate, IGF-I exists in multiple isoforms (tissue-specific proteins of functional and structural similarity). One isoform, which differs from the systemic or liver type, happens to be particularly sensitive to mechanical signals such as the gamut of exercise overload. MGF is a local splice variant of IGF-I produced by damaged or loaded skeletal muscle (Dluzniewska J, et al.., 2005 p. 1). The physiological function of MGF was studied using an in vitro cell model. Unlike mature IGF-I, the distinct E domain of MGF inhibits terminal differentiation whilst increasing myoblast proliferation. Blocking the IGF-I receptor with a specific antibody indicated that the function of MGF E domain is mediated via a different receptor. The results provide a basis for localized tissue adaptation and helps explain why loss of muscle mass occurs in the elderly and in dystrophic muscle in which MGF production is markedly affected (Yang SY, Goldspink G., 2002, p. 156-60). Ok, enough of the science. I am sure your brain is probably hurting after reading that, I know mine was. In really simple terms, MGF is a variant of IGF-1, an isoform that is particularly sensitive to muscle trauma (weight training) and is essential for repair and growth of new cells, similar in manner to IGF-1. What you need to know is MGF triggers new cell growth or hyperplasia in rat testing, and since we as bodybuilders fancy ourselves as lab rats, it is currently the in vogue peptide by top amateurs and pro’s. Well all of this sounds great but what is the catch? This is where we reach a cross-road, a potential problem with MGF. As great as MGF has been in clinical trials and rat studies, the fact is that injected MGF has a half life of minutes….yes minutes. So how are you going to make this work, besides injecting every hour or so of your waking day? The answer lies in a little known molecule protection agent knows as PEGylation. So what is or PEGylation? In simple terms it is the process of attaching one or more chains of a substance called polyethylene glycol (PEG) to a protein molecule such as IGF or in this case MGF. Since the body does not react to PEG, it helps provide a protective barrier around an attached protein so it can survive in the body longer. This is highly beneficial for systemic products that must survive repeated attacks by enzymatic exposure. PEG is an inert non-toxic substance that can provide protection to amine groups since they are flexible and allow attachment by bioengineered processes to the receptor bearing cell. Finally a quick explanation of polyethylene glycol; Any of a family of high molecular weight compounds that can be liquid or wax-like in consistency and are soluble in water and in many organic solvents. Polyethylene glycol itself does not react in the body and is very safe. PEG has been approved by the US Food and Drug Administration (FDA) as a base or vehicle for use in foods and cosmetics and in injectable, topical, rectal and nasal pharmaceutical formulations. The risk associated with current PEGylated drugs are due to the way the drug itself acts not the PEG. PEGylation can improve dosing convenience of many small molecules by increasing bioavailability and reducing dosing frequency. PEGylation also increases the amount of time the cell sits at the target site. This can be both good and bad. It is good because it increases the drug concentration, and with a longer time at the site, there is more chance of uptake by the cell. The bad news is that while it is sitting at the cell, there is increased risk of damage by enzymes that attack the cell. This is a double-edge sword that is a necessary evil; you must protect the molecule but at the same time increase the risk factor of damage due to longer exposure times at the target cell. As a result of the increased time at the cell, the optimal drug concentration can be achieved with less frequent dosing; a significant benefit to bodybuilders who are usually using poly-pharmacy at its finest. PEGylated MGF is systemic in nature, meaning that the method of administration is not important. Most people are using MGF in a fashion similar to IGF, meaning they inject the peptide intramuscularly in recently trained muscle groups, hoping for an increase in cell repair and proliferation of new cells. While this thinking is optimistic at best, there is no research that would support site specific injections being beneficial for localized growth. This is a myth that has purveyed aas and peptide use for years. At this time, the literature and lab studies support subcutaneous injection, using small gauge insulin syringes. Obviously there are no human research trials at this time; the peptide is still in research phases. Bodybuilder use at this time is all by trial and error. One company that currently carries MGF has conducted their own research trials, using test participants from underground steroid boards who are providing feedback in weekly intervals. While this is hardly a controlled environment and may have to many variables to accurately assess the product, at least it is a start. I have also been conducting my own research, on myself and my clients, who often refer to themselves as Gavin’s guinea pigs. As with most peptides, more is not better. Smaller doses with less frequent injection schedules have proven to be optimal. I personally have been using 200mcg injected sub-q, two times per week. I have had my clients try 100mcg, two times per week, three times per week, daily, etc. So far the best results have been my personal method, 200mcg, two times per week. Elite athletes are experiencing incredible body fat loss, increased pumps, fullness, and vascularity. I was able to gain 6 pounds of lean mass and lose 4.2% body fat in 4 weeks of use. I kept using it for weeks 5 and 6 but with no further gains or body fat loss. It seems that MGF stalls out at the 4 week mark, my theory being that much like with media grade IGF-1 LR3, the cells reach super saturation and cannot process any further uptake of the peptide sequence. It is possible to bypass this saturation, but it will take some time to work out the differential nature of the timing, much like I had to do with IGF-1 LR3, where I have now found ways to take it for up to 20 weeks with little to no cell down-regulation. At this time all use and injection schedules are by word of mouth, sometimes by erroneous information on underground boards. Proper use of MGF is merely by speculation; it will take some time to sort out the best method of administration, although with the ever changing world of science, where nothing ever stands still, it may take years to sort out optimal dosing schedules. Even with such stable peptide structures as growth hormone that have had years of research, new information is always being studied, and I speculate that it will with all peptides.

Sermorelin TOP

Sermorelin is used in the treatment of prevention of HIV-induced weight loss, children with growth hormone deficiency or growth failure. Sermorelin should be considered a valuable alternative to HGH by anti-aging practitioners seeking to provide the best and most contemporary interventions in aging for their patients. 2mg/vial or according to your requirement Worldwide shipment USES: Sermorelin is used to treat growth problems (usually in children) due to growth hormone deficiency. It works by stimulating the pituitary gland to release more natural growth hormone. HOW TO USE: Learn how to prepare and inject the drug. Review the sermorelin Patient Information Insert. If any of the information is unclear, consult your doctor or pharmacist. When mixing this medication with a saline solution, aim the syringe containing the mixing solution (saline) against the inside wall of the vial; slowly inject the solution so it runs down the side of the vial and into the medication powder. Do not inject the solution directly into the medication. Doing so may cause this medication to be ineffective. Gently swirl the mixture until all the medication is dissolved completely. Do not shake the vial. Inject this medication under the skin (subcutaneously) usually once daily at bedtime; or use as directed by your doctor. The dosage is based on your weight, medical condition, and response to therapy. Before injecting each dose, clean the injection site with rubbing alcohol. It is important to change the location of the injection site daily to avoid problem areas under the skin. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Do not mix this medication to be used at a later time. Only use freshly mixed medication. Learn how to store and discard needles and medical supplies safely. Consult your pharmacist. SIDE EFFECTS: Pain/swelling/redness of the injection site may occur. If any of these effects persist or worsen, notify your doctor. Promptly tell your doctor if any of these unlikely side effects occur: headache, flushing, increase in activity (hyperactivity). Tell your doctor immediately if any of these unlikely but serious side effects occur: trouble swallowing, vomiting, tightness in the chest. An allergic reaction to this drug is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include: rash, itching, swelling, dizziness, trouble breathing. If you notice other effects not listed above, contact your doctor or pharmacist. PRECAUTIONS: Tell your doctor your medical history, especially of: thyroid problems (e.g., hypothyroidism), brain disorders (e.g., lesions), any allergies. This medication should be used only when clearly needed during pregnancy. Discuss the risks and benefits with your doctor. It is not known whether this drug passes into breast milk. Because of the potential risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.  DRUG INTERACTIONS: Tell your doctor of all prescription and nonprescription medication you may use, especially: corticosteroids (e.g., prednisone), thyroid medications (e.g., levothyroxine). This drug may affect the results of certain lab tests (e.g., inorganic phosphorus, alkaline phosphatase). Make sure laboratory personnel and your doctors know you use this drug. Do not start or stop any medicine without doctor or pharmacist approval. OVERDOSE: If overdose is suspected, contact your local poison control center or emergency room immediately. US residents can call the US national poison hotline at 1-800-222-1222. Canadian residents should call their local poison control center directly. NOTES: Do not share this medication with others. Laboratory and/or medical tests (e.g., bone age, height measurement, thyroid hormone levels) may be performed to monitor your progress. MISSED DOSE: If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up. STORAGE: Before mixing, store the dry powder vials in a refrigerator between 36 and 46 degrees F (2 and 8 degrees C). Once mixed, the medication solution should be used immediately. Discard any unused portion of the vial(s).

GHRP-6 TOP

Benefits of increased Growth Hormone levels through GHRP-6 stimulation include: an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide which specifically stimulates secretion of growth hormone (GH) by pituitary somatotrophs. Sometimes, GHRP-6 combines with CJC-1295, there will be an amazing result. High quality GHRP-6 and worldwide shipment: 5mg/vial   GHRP-6 is a peptide in the growth factor family.  It has strong effect on the release of Growth Hormone (GH).  Its main use is to promote food intake by stimulating hunger and aid in energy metabolism.   It can be used in the treatment of GH deficiency as well as cachexia, eating disorders and obesity. Background Although still relatively new, peptides have recently become popular as performance enhancing drugs.  GHRP-6 is currently available from a few research companies. Action The major side effect accompanied by the use of GHRP-6 is a significant increase in appetite due to a stimulating the release of Ghrelin, a peptide which is released naturally in the lining of the stomach and increases hunger and gastric emptying.  GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release.  Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release, when natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH.   GHRP-6 also affects the central nervous system, by protecting neurons as well as increasing strength in a way very similar to the way certain steroids in the Dihydrotestosterone family do. Benefits of increased Growth Hormone levels through GHRP-6 stimulation include:  an increase in strength, muscle mass and body fat loss, rejuvenation and strengthening of joints, connective tissue and bone mass. Enhanced GH secretion also leads to the liver secreting more IGF-1 (Insulin-Like Growth Factor 1), which is thought to be the primary anabolic mechanism of action for Growth Hormone. Technical Data It has also been discovered that when GHRP-6 and insulin are used simultaneously, GH response to GHRP-6 is increased (1). A recent study in normal mice showed significant differences in body composition, muscle growth, glucose metabolism, memory and cardiac function in the mice being administered the GHRP-6 (2).  There are still many questions regarding this fairly new compound, scientists are hoping with to gain a better clinical understanding of the peptide through further research over the next few years. User Notes I used this stuff at a dose of 500-600 mcg/day for awhile and found that the weight gain (mostly from an increase in my appetite) was far too great. I gained a ton of weight (on par with the most potent anabolics) but it wasn’t pretty. The effects on my joints were very beneficial at that dose also, but I didn’t really find much of a drop off when I lowered the dose to 100-200 mcg/day. In fact, I have a sprinter friend who ran a personal best with a combination of low dose GHRP-6 (100-150 mcg/day or so) and Anavar (20 mgs); that wouldn’t be a huge deal but for the fact that this was done while rehabilitating an injury! On the other hand, even that low dose was too much for a figure competitor I know, who gained far too much weight from using GHRP-6 and ultimately had to discontinue using it after only a couple weeks. Although this stuff can have GH-like effects, the weight increase makes any possible fat burning effects almost unnoticeable. For a bulking cycle, and at the price, it’s almost a must-have, if you’re looking to gain a ton of weight or trying to rehab an injury.

CJC1295 TOP

CJC-1295 is a Long-acting growth-hormone-releasing hormone (GHRH) analog. Because of the long half-life and stability of the CJC-1295 analog, it appears to become more and more popular. We have got many satisfied feedbacks from customers. Over 99% purity CJC-1295 and worldwide shipment: 1mg/vial or 2mg/vial   CJC-1295 is a Long acting GHRH analog. Growth-hormone-releasing hormone (GHRH), also known as growth-hormone-releasing factor (GRF or GHRF) or somatocrinin, is a 44-amino acid peptide hormone produced in the hypothalamus by the arcuate nucleus. GHRH stimulates growth hormone (GH) secretion from the pituitary. GHRH is released in a pulsatile manner, stimulating pulsatile release of GH respectively. In addition, GHRH also promotes slow-wave sleep . The active portion of this GRF or GHRH peptide can be found as a 29 amino acid long peptide and is appropriately named GHRH1-29. This pulsatile release of various peptides is due to the negative feedback loop that is part of the hGH axis and controls the amount of hGH that your body produces to keep it in a homeostatic environment. Despite the effectiveness of GHRH to stimulate growth hormone release there are a number of problems associated with using it in vivo. The most noteworthy problem is the half life of the peptide, which has been shown to be ~7 minutes using advanced HPLC technologies that have proven to be very accurate. The reason for this relatively short half life is due to an enzyme called dipeptidylaminopeptidase IV (DPP-IV), which has a high affinity for the amino acids Ala and Pro and in the case of GHRH it cleaves the 1 and 2 positions that consist of Tyr-Ala, creating GHRH3-29, an inactive form of the peptide. To prevent the problems associated with natural GHRH, pharmaceutical companies looked at new ways to increase the half life and bioavailability of these smaller peptides with technologies that work far different than other technologies, such as PEGylation. CJC-1295 is a synthetic modification of growth hormone releasing factor (GRF) with D-Ala, Gln, Ala, and Leu substitutions at positions 2, 8, 15, and 27 respectively. These substitutions create a much more stable peptide with the substitution at position 2 to prevent DPP-IV cleavage, position 8 to reduce asparagine rearrangement or amide hydrolysis to aspartic acid, position 15 to enhance bioactivity, and position 27 to prevent methionine oxidation. By applying the Drug Affinity Complex (DAC) technology to GRF, the peptide selectively and covalently binds to circulating albumin after subcutaneous (SC) administration, thus prolonging its half-life. These substitutions are key in increasing the overall half life of CJC-1295 but there lies an even greater reason as to why the half life has been extended from ~7 minutes to greater than 7 days! Bioconjugation is a relatively newer technology that takes a reactive group and attaches it to a peptide, which in turn reacts with a nucleophilic (usually a partially negative molecule) entity found in the blood to form a more stable bond. Albumin, one of the most abundant substances in the human body is chosen as the nucelophile by this particular peptide thanks to a Cys34 thiol group that attracts it. By combining the tetrasubstituted GHRH analogue with maleimodoproprionic acid using a Lys linker, you create a GHRH peptide with a high binding affinity for albumin. Once the CJC-1295 molecule has attached itself to albumin, it is given an extended half life and bioavailability thanks to the albumin preventing enzymatic degredation and kidney excretion. In fact, bioconjugation is so effective that there was less than 1% of CJC-1295 left unreacted in vivo and over 90% was stabilized after subcutaneous injection. This means that you get more of what you paid for working for you. There was no DPP-IV degredation observed on CJC -1295 in any of the various experiments conducted. Various experiments have been conducted to test the effectiveness of CJC -1295 in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10 fold for more than 6 days and increased IGF-1 concentrations 1.5-3 fold for 9-11 days after a single injection!